Prostacyclins and use as medicinal agents

Abstract

Prostane derivatives of the formula ##STR1## wherein B is straight-chain or branched alkylene of 1-10 carbon atoms, A is --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH--, or --C.tbd.C--; W is hydroxymethylene or a ##STR2## wherein the OH-group can be in the .alpha.- or .beta.-position, and is optionally modified by replacement of the H atom with an ether or acyl group which is conventional for such replacements in prostaglandins and which is readily cleavable at physiological pH's; D and E together are a direct bond or D is straight-chain or branched alkylene of 1-10 carbon atoms, or, such an alkylene of 4-10 carbon atoms containing a double bond in the 2- or 3- position, all of which can optionally be substituted by fluorine, 1,2-methylene, 1,1-trimethylene, or methoxy; E is oxygen, sulfur, --C.tbd.C-- or a direct bond; R.sub.2 is C.sub.1-10, C.sub.2-10 alkenyl, each of which optionally is substituted phenyl, 1-naphthyl or 2-naphthyl, each of which is substituted as defined below; C.sub.4-10 cycloalkyl optionally substituted by C.sub.1-4 alkyl; phenyl, 1-naphthyl, or 2-naphthyl, each of which can optionally be substituted by 1-3 halogen atoms, a phenyl group, 1-3 alkyl groups each independently of 1-4 carbon atoms, or a chloromethyl, fluoromethyl, trifluoromethyl, carboxy, C.sub.1 -C.sub.4 -alkoxy, or hydroxy group, or an aromatic 5- or 6-membered heterocyclic ring having one hetero ring atom which is O, N, or S, the remaining atoms being carbon; and R.sub.1 is hydroxy optionally modified as for W above, have valuable vasodilating, anti-hypertensive, and bronchodilating pharmacological properties.

Dependencies are inferred from the claim text.