Loading patent…
AssigneesTeijin Limited, Teijin Pharmaceutical Co., Ltd.
InventorsMamoru Kiyoki, Hiroyoshi Endo, Tatsuyuki Naruchi, Yoshinobu Hashimoto
Estimating the term…
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1.alpha., 24-dihydroxycholecalciferol (1.alpha., 24-DHCC) and 24,25-dihydroxycholecalciferol (24,25-DHCC) to said warm-blooded animal, and a pharmaceutical composition comprising 1.alpha.,24-DHCC, 24,25-DHCC and a pharmaceutically acceptable carrier. According to the invention, a condition of abnormal bone metabolism requiring long-term therapy, such as osteoporosis, can be safely treated by administering 1.alpha., 24-DHCC and 24,25-DHCC over a long period of time because no substantial adverse effect of 1.alpha., 24-DHCC on the metabolis of 24,25-DHCC is observed.
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1.alpha.,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to the warm-blooded animal, said amount being sufficient to bring abnormal bone metabolism to a normal bone metabolism or to maintain normal bone metabolism.
A method for remedying abnormal bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1.alpha.,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to the warm-blooded animal said amount being sufficient to bring abnormal bone metabolism to a normal bone metabolism.
A method for preventing the abnormal bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of a 1.alpha.,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to the warm-blooded animal said amount being sufficient to maintain normal bone metabolism.
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1.alpha.,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to said warm-blooded animal said amount being sufficient to bring abnormal bone metabolism to a normal bone metabolism or to maintain normal bone metabolism so that the calcium level in the serum of said warm-blooded animal is maintained at 8 to 12 mg/dl of serum.
A pharmaceutical composition for regulating the bone metabolism of a warm-blooded animal which comprises a pharmaceutically effective amount of a mixture of 1.alpha.,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
A medicament for regulating the bone metabolism of a warm-blooded animal in unit dosage form comprising a unit dosage of 1.alpha.,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
A medicament for oral administration for regulating the bone metabolism of a warm-blooded animal in unit dosage form comprising 0.05 to 10 .mu.g of 1.alpha.,24-dihydroxycholecalciferol and 0.5 to 25 .mu.g of 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.