Production of immunogenic products and treatment of allergic reactions therewith
OwnerGijsberk T. Hoekinventor
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Abstract
A method for the production of immunogenic products useful in the therapeutic treatment of allergic conditions in patients, comprising the solvent extraction from allergenic substances of the solvent soluble components thereof to obtain the residue of extraction which may be employed as an immunogenic material possessing reduced allergenicity. If desired, the thus obtained residue of extraction may be further treated with a suitable ketone, aldehyde, lactone or epoxide to yield a product having enchanced immunogenic properties and reduced toxicity.
Claims7
A method of preparing an immunogenic product useful in the therapeutic treatment of patients suffering from allergic conditions, and which product possesses reduced allergenic properties, which comprises extracting an allergenic product by treatment thereof with a suitable solvent selected from the group consisting of water, alcohol, glycerol, dimethyl sulfoxide and phenol, in which the allergens to be extracted are soluble, until most of the soluble allergens contained in said allergenic product are extracted therefrom, discarding the solute thus obtained, and recovering the extracted residue thereof which contains no more than 1:100 w/w of its original allergen content, to yield the desired immunogenic product.
A method of preparing an immunogenic product useful in the therapeutic treatment of patients suffering from allergic conditions, and which product possess reduced allergenic properties, which comprises extracting an allergenic product by treatment thereof with a suitable solvent until most of the soluble antigens contained therein are extracted therefrom, discarding the solute thus obtained, recovering the extracted residue thereof which contains no more than 1:100 w/w of its original allergen content, and further treating said extracted residue with .beta.-propiolactone, the weight ratio of .beta.-propiolactone to said residue being between 1:1 and 1:100, and removing all said .beta.-propiolactone to yield the desired final product.
Dependencies are inferred from the claim text.