Stable diagnostic reagents
AssigneeMedi-Physics, Inc.
InventorHarry S. Winchell
Life of this patent
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Abstract
Diagnostic reagents comprising a chelating agent and stannous tin which are suitable for conversion to radiopharmaceuticals by the addition of a radionuclide, such as suitable forms of technetium 99m, are stabilized against oxidation and/or hydrolysis by the addition to said complex of ascorbic acid, erythorbic acid, pharmaceutically acceptable inorganic salts thereof or mixtures thereof.
Claims14
A method of stabilizing a reagent suitable for the preparation of a radiopharmaceutical by the addition thereto of a radionuclide, said reagent comprised of a chelating agent and stannous ion comprising adding to said chelate from about 1 mole to about 100 moles of a substance selected from the group consisting of ascorbic acid, erythorbic acid, pharmaceutically acceptable inorganic salts thereof and mixtures thereof for each mole of stannous ion.
A stable reagent suitable for the preparation of a radiopharmaceutical by the addition thereto of a radionuclide which comprises a chelating agent, stannous ion and from about 1 mole to about 100 moles of a stabilizing compound selected from the group consisting of ascorbic acid, erythorbic acid, pharmaceutically acceptable inorganic salts thereof or mixtures thereof.
A stable composition useful in the production of technetium-99 m based scanning agents comprising a stannous reducing agent, ethane-1-hydroxy-1,1-diphosphonic acid, and an effective amount of ascorbic acid sufficient to stabilize the composition.
A stable composition useful in the production of technetium-99m based scanning agents, comprising a stannous reducing agent, a chelating agent and an effective amount of ascorbic acid to stabilize the composition.
Dependencies are inferred from the claim text.