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US 4,363,912 AGranted
Indole thromboxane synthetase inhibitors
AssigneePfizer Inc.
InventorsPeter E. Cross, Roger P. Dickinson
Life of this patent
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Abstract
A series of novel 3-(pyrid-3- or -4-ylalkyl)-indoles useful as inhibitors of the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacyclin synthetase or cyclo- oxygenase enzymes is disclosed.
Claims7
Compounds of the formula:
- ##STR26## where R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.7 cycloalkyl or phenyl;
- R.sup.2 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, or halo;
- R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl;
- X is --(CH.sub.2).sub.n -- where n is 1, 2 or 3, --CH.sub.2 CH(CH.sub.3)-- or ##STR27## Y is --COOH, --COO (C.sub.1 -C.sub.4 alkyl), --CONH.sub.2, --CN or 5-tetrazolyl;
- and Z is 3- or 4-pyridyl;
- and the pharmaceutically acceptable salts thereof.
3 more elements
A compound of the formula:
- ##STR28##
Dependencies are inferred from the claim text.