1,2-Dihydro-6-[2-(dimethylamino)ethenyl]-2-oxo-5-(pyridinyl) nicotinonitriles
AssigneeSterling Drug Inc.
InventorsGeorge Y. Lesher, Ruth P. Brundage
Life of this patent
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Abstract
1-R.sub.1 -1,2-dihydro-6-[2-(dimethylamino)ethenyl]-2-oxo-5-PY-nicotinonitriles, where R.sub.1 is hydrogen or methyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, or pharmaceutically acceptable acid-addition salts thereof are useful as cardiotonic agents. Said compounds are prepared by reacting 1,2-dihydro-6-methyl-2-oxo-5-PY-nicotinonitrile with dimethylformamide dimethylacetal. Shown is the cardiotonic use of said compounds or pharmaceutically acceptable acid-addition salts thereof.
Claims4
A compound having the formula ##STR2## or acid-addition salt thereof, where R.sub.1 is hydrogen or methyl, and PY is 4-pyridinyl or 3-pyridinyl, or 4-pyridinyl or 3-pyridinyl having one or two lower-alkyl substituents.
Dependencies are inferred from the claim text.