Enol acylate analogs of E.sub.1 and E.sub.2 prostaglandins

Prostaglandin C-9 enol acylate analogs characterized by the formula:

• ##STR39## wherein:
• the dashed line in the cyclopentyl ring represents the presence of a double carbon-carbon bond at either C.sub.8 -C.sub.9 or C.sub.9 -C.sub.10 ;
• Z is cis vinylene or ethylene;
• n is 0 or 1;
• A represents the presence of a single carbon-carbon bond between C.sub.7 and C.sub.8 which is in the .alpha. configuration when there is a double carbon-carbon bond between C.sub.9 and C.sub.10 and is in the plane of the 5 membered ring when there is a double carbon-carbon bond between C.sub.8 and C.sub.9 ;
• X is CH.sub.2 OH, CH.sub.2 OCOCH.sub.3, CONHR.sub.4, CO.sub.2 M where M is H.sup.+, K.sup.+, 1/2 Ca.sup.++, NH.sub.3.sup.+ C (C.sub.2 H.sub.5 OH).sub.3 or another pharmacologically acceptable salt cation, CH.sub.3 or C.sub.2 H.sub.5 ;
• R.sub.1 is n-alkyl of 1 to 20 carbon atoms which is optionally replaced with oxa groups, cyclic alkyl or 3 to 12 carbon atoms optionally replaced with nitrogen to form an imido group of the formula ##STR40## bicyclic alkyl of 7 to 12 carbon atoms, aryl of 6 to 12 carbon atoms optionally substituted with an n-alkyl group of 1 to 10 carbon atoms or one or more halogen atoms, alkenyl (Z and/or E) of 2 to 12 carbon atoms, alkenyl-alkyl of 3 to 12 carbon atoms or O-n-alkyl of 1 to 20 carbon atoms wherein all of the above are optionally substituted with CO.sub.2 M, CONHR.sub.4 or acetate;
• R.sub.2 is H, n-alkyl of 1 to 10 carbon atoms, branched alkyl of 3 to 10 carbon atoms, cyclic alkyl of 3 to 10 carbon atoms optionally substituted with n-alkyl of 1 to 10 carbon atoms, bicyclic alkyl of 7 to 12 carbon atoms, aryl of 6 to 12 carbon atoms optionally substituted with n-alkyl of 1 to 10 carbon atoms or halogen, R.sub.3 is a moiety coming within the definition of R.sub.2 except that R.sub.3 is not H;
• and R.sub.4 is H or a moiety coming within the definition of COR.sub.1.