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US 4,363,809 AGranted
Organic compounds
AssigneeSandoz Ltd.
InventorsMagda Marko, Hendricus B. A. Welle
Life of this patent
Estimating the term…
Abstract
Method of inhibiting luteinising hormone secretion in a subject, said method comprising administering an optionally 5-alkyl- or -phenyl- and/or 2'-hydroxy-, -alkoxy- or -acyloxy-substituted 9,9-dimethyl-6,7-benzomorphan derivative having an oxygen containing substituent at the N-atom.
Claims10
A method of inhibiting luteinizing hormone secretion in a subject in need of such treatment, which method comprises administering to said subject a luteinizing hormone inhibiting effective amount of a compound of formula I, ##STR2## wherein A is a direct bond or --CH.sub.2 --,
- R.sub.1 is hydrogen, C.sub.1-3 alkyl, C.sub.2-3 alkenyl, C.sub.2-3 alkynyl, C.sub.1-2 alkoxy, C.sub.1-2 alkyl or C.sub.3-6 cycloalkyl,
- R.sub.2 is hydrogen or C.sub.1-3 alkyl, or
- R.sub.1 and R.sub.2, together with the carbon atom to which they are attached, form a C.sub.3-6 -cycloalkyl group or a 4 to 6-membered heterocycloalkyl group containing one oxygen atom as the solo hetero atom,
- R.sub.3 is hydroxy, C.sub.1-4 alkoxy, C.sub.2-4 alkenyloxy, or R.sub.6 COO-- in which R.sub.6 is hydrogen, C.sub.1-3 -alkyl, phenyl or benzyl,
- R.sub.4 is hydrogen, C.sub.1-4 alkyl or phenyl, and
- R.sub.5 is hydrogen, hydroxy, C.sub.1-3 alkoxy or R.sub.7 COO-- where R.sub.7 is hydrogen, C.sub.1-3 alkyl, phenyl, benzyl, phenethyl or 3-pyridyl.
3 more elements
Dependencies are inferred from the claim text.