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US 4,362,877 AGranted
2,4-Disubstituted-1,2,5-thiadiazol-3(2H)-one antimicrobials
AssigneeMerck & Co., Inc.
InventorsRichard A. Dybas, Bruce E. Witzel, Nathaniel Grier
Life of this patent
Estimating the term…
Abstract
2,4-Disubstituted-1,2,5-thiadiazol-3(2H)-one antimicrobials have broad spectrum antibacterial and antifungal activity. They are found to be especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.
Claims6
A compound of the formula:
- ##STR25## where R is C.sub.1 to C.sub.18 alkyl linear or branched;
- phenyl --C.sub.1 to C.sub.10 alkyl, phenyl, and phenyl independently mono- or di-substituted with bromine, chlorine, fluorine and iodine, alkyl containing from C.sub.1 to C.sub.12 carbon atoms or alkoxy having the same number of carbon atoms;
- and R.sup.1 is C.sub.1 to C.sub.18 alkyl, linear or branched;
- loweralkoxyalkyl wherein the alkoxy group contains from one to six carbon atoms and the alkyl moiety from one to four carbon atoms, tetrahydrofuran-2-ylmethyl, and phenyl-C.sub.1 to C.sub.10 alkyl;
- ring substituted or disubstituted phenyl C.sub.1 to C.sub.10 alkyl where said substituent is the same or different and said substituent is bromine, chlorine, fluorine or iodine, C.sub.1 to C.sub.12 alkyl or C.sub.1 to C.sub.12 alkoxy.
2 more elements
A compound selected from the group consisting of:
- 2-(4-Chlorophenylmethyl)-4-methyl-1,2,5-thiadiazol-3-one
- 2-(3,4-Dichlorophenylmethyl-4-methyl-1,2,5-thiadiazol-3-one
- 2-Phenyl-4-methyl-1,2,5-thiadiazol-3-one
- 2-n-Hexyl-4-methyl-1,2,5-thiadiazol-3-one
- 2-n-Propyl-4-(phenylmethyl)-1,2,5-thiadiazol-3-one
- 2-n-Propyl-4-(4-chlorophenylmethyl)-1,2,5-thiadiazol-3-one
- 2-n-Propyl-4-(3,4-Dichlorophenylmethyl)-1,2,5-thiadiazol-3-one
- 2-(4-Chlorophenyl)-4-methyl-1,2,5-thiadiazol-3-one
- 2-(4-Chlorophenylmethyl-4-(tetrahydrofuran-2-ylmethyl)-1,2,5-thiadiazolone
6 more elements
Dependencies are inferred from the claim text.