Process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose
AssigneeTalres Development (N.A.) N.V.
InventorsMichael R. Jenner, David Waite, Graham Jackson, John C. Williams
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Abstract
4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose is prepared by a process including the steps of: (a) isomerizing 2,3,4,3',4'-penta-O-acetyl sucrose to 2,3,6,3',4'-penta-O-acetyl sucrose; (b) chlorinating the isomerized acetate at the 4,1' and 6'-positions; and (c) deacetylating the resulting chlorinated product; the isomerization step (a) being effected by treating a solution of 2,3,4,3',4'-penta-O-acetyl sucrose in an inert solvent with a weak acid at an elevated temperature.
Claims12
In a process for the production of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose including the steps of (a) isomerising 2,3,4,3',4'-penta-O-acetyl sucrose to 2,3,6,3',4'-penta-O-acetyl sucrose;
- (b) chlorinating the isomerised acetate at the 4,1', and 6'-positions and (c) deacetylating the chlorinated product, the improvement comprising effecting the isomerisation step (a) by treating a solution of 2,3,4,3',4'-penta-O-acetyl-sucrose in an inert solvent with a weak acid having an acid strength on the same order as acetic acid at an elevated temperature of at least about 80.degree. C.
Dependencies are inferred from the claim text.