Antibacterial monic acid esters
AssigneeBeecham Group Limited
InventorsNorman H. Rogers, Peter J. O'Hanlon, Graham Walker
Life of this patent
Estimating the term…
Abstract
Compounds of formula (II): ##STR1## in which Y represents ##STR2## and R.sub.0 represents a C.sub.2-20 alkyl, C.sub.3-8 cycloalkyl, C.sub.4-20 alkenyl, arakyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl group, which is substituted by a hydroxyiminohydrazono- or semicarbazono group, have activity against human and veterinary bacteria and mycoplasma. They may be produced by conventional methods and are used in conventional formulations.
Claims7
A compound of formula (II) ##STR14## in which Y represents ##STR15## and R.sub.0 represents C.sub.2-20 alkyl, C.sub.3-8 cycloalkyl, C.sub.4-20 alkenyl, phenylalkyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl wherein said heterocyclyl is a five or six-membered heterocyclic ring containing oxygen, sulfur or nitrogen as the sole heteroatom, said heterocyclic ring being unsubstituted or substituted by lower alkyl, which is substituted by a hydroxyimino-, hydrazono- or semicarbazono group.
A compound selected from:
- 4-Hydroxyimino-4-phenylbutyl monate A
- 4-Phenyl-4-semicarbazonobutyl monate A
- 4-Hydroxyiminocyclohexyl monate A
- 4-Hydroxyimino-4-(2-thienyl)butyl monate A
- 4-Methoxyimino-4-phenylbutyl monate A
- 6-Dimethylhydrazonohexyl monate A
- 5-Hydroxyiminomethylfurfuryl monate A, and
- m-Hydroxyiminomethylbenzyl monate A.
Dependencies are inferred from the claim text.