Pyrrolo(2,3-d)carbazole derivatives, compositions and use
AssigneeOmnichem
InventorMartin E. Kuehne
Life of this patent
Estimating the term…
Abstract
This invention relates to alkyl pyrrolo(2,3-d) carbazole-6-carboxylates having antianoxic, psychotropic and hemodynamic properties and to addition salts thereof; and to preparation of the same by a synthesis sequence starting from a tryptamine and a 3-halopyruvate and involving a rearrangement of an addition compound with an aldehyde, said rearrangement being effected by Nb-alkylation of the aforementioned addition compound; and to pharmaceutical compositions containing the same; and to tetrahydroazepinoindoles used in the preparation of the same.
Claims19
A compound of the formula ##STR10## wherein R.sub.1 and R.sub.5 each represents hydrogen, lower alkyl, or benzyl;
- R.sub.2 and R.sub.3 each represents hydrogen or lower alkyl or, together, lower alkylene;
- R.sub.4 is lower alkyl;
- R.sub.6 is hydrogen, nitro, lower alkoxy, halo or hydroxy;
- or an addition salt of said compound.
Dependencies are inferred from the claim text.