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AssigneeYamanouchi Pharmaceutical Co., Ltd.
InventorsYasufumi Hirata, Isao Yanagisawa, Yoshio Ishii, Masaaki Takeda
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Novel guanidinothiazole compounds of the general formula ##STR1## wherein R represents a hydrogen atom or a lower alkyl group, Y represents a sulfur atom or a methylene group, m and n each represents an integer of 1-3, A represents the group shown by ##STR2## (wherein R.sub.1 represents a hydrogen atom, a cyano group, a carbamoyl group, a ureido group, a hydroxyl group, a lower alkoxy group, a lower acyl group, an acylamino group, an arylsulfamoyl group, an aralkyl group or a carboxymethyl group, an arylsulfamoyl group, an aralkyl group or a carboxymethyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cyano group or a lower acyl group, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group or a sulfamoyl group), and the pharmacologically acceptable acid addition salts thereof; these compounds are useful as gastric acid secretion inhibitors.
A guanidinothiazole compound of the formula ##STR66## wherein R represents a hydrogen atom or a lower alkyl group, Y represents a sulfur atom or a methylene group, m and n each represent an integer of 1-3, A represents the group ##STR67## wherein R.sub.1 represents a member selected from the group consisting of a hydrogen atom, a cyano group, a carbamoyl group, a ureido group, a hydroxyl group, a lower alkoxy group, a lower alkylcarbonyl group of a straight or branched carbon chain having 1-5 carbon atoms, a lower alkylcarbonylamino group of straight or branched carbon chain having 1-5 carbon atoms, a benzoylamino group, a naphthoylamino group, a --NH--SO.sub.2 -phenyl group, a --NH--SO.sub.2 -naphthyl group, a benzyl group, a phenethyl group, and a carboxymethyl group, R.sub.2 represents a member selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cyano group, and a lower alkylcarbonyl group of a straight or branched carbon chain having 1-5 carbon atoms, and R.sub.3 represents a member selected from the group consisting of a hydrogen atom, a lower alkyl group, a hydroxyl group, and a sulfamoyl group, and the pharmacologically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.