3-[(3-Oxo-1-butenyl)amino]-5-(pyridinyl)-2(1H)-pyridinones and their cardiotonic use
AssigneeSterling Drug Inc.
InventorsGeorge Y. Lesher, Ruth P. Brundage
Life of this patent
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Abstract
1-R.sub.1 -3-[(1-Methyl-3-oxo-1-butenyl)amino or (3-oxo-1-butenyl)amino]-5-PY-6-R-2(1H)-pyridinones, where R.sub.1 is hydrogen or lower-alkyl, PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents and R is hydrogen or lower-alkyl, or pharmaceutically acceptable acid-addition salts thereof are useful as cardiotonic agents. The preparation and cardiotonic use of said compounds are shown.
Claims11
A compound having the formula ##STR2## or acid-addition salt thereof, where R' is hydrogen or methyl, R.sub.1 and R are each hydrogen or lower-alkyl, PY is 4-pyridinyl or 3-pyridinyl, or 4-pyridinyl or 3-pyridinyl having one or two lower-alkyl substituents.
Dependencies are inferred from the claim text.