Haloguanidine compounds, pharmaceutical compositions and methods of use

A guanidine derivative of the formula:

• ##STR32## in which R.sup.1 and R.sup.2, which may be the same or different, are hydrogen atoms or branched or unbranched alkyl radicals of 1 to 10 carbon atoms, cycloalkyl radicals of 3 to 8 carbon atoms or cycloalkylalkyl radicals in which the alkyl part is of 1 to 6 carbon atoms and the cycloalkyl part is of 3 to 8 carbon atoms, each of the alkyl, cycloalkyl and cycloalkylalkyl radicals being optionally substituted by one or more halogen atoms selected from fluorine, chlorine and bromine atoms, provided that at least one of R.sup.1 and R.sup.2 is a halogen substituted alkyl, cycloalkyl or cycloalkylalkyl radical and provided that there is no halogen substituent on the carbon atom of the alkyl, cycloalkyl or cycloalkylalkyl radical which is directly attached to the nitrogen atom;
• ring X is a pyridine, pyrimidine, pyrazine, pyridazine or triazine ring which may, where possible, carry a single optional substituent, the optional substituents on ring X being selected from fluorine, chlorine, bromine and iodine atoms and alkyl, alkoxy and alkylthio radicals of 1 to 6 carbon atoms, trifluoromethyl, hydroxy and amino radicals;
• Y is an oxygen or sulphur atom, a direct bond, a methylene, cis or trans vinylene or sulphinyl radical or a radical of the formula NR.sup.4 in which R.sup.4 is a hydrogen atom or an alkyl radical of 1 to 6 carbon atoms;
• m is 0 to 4 and n is 1 to 5, provided that when Y is an oxygen atom, a sulphinyl radical or a radical of the formula NR.sup.4, n is 2 to 5;
• R.sup.3 is a radical of the formula --A--B in which A is a 3,4-dioxocyclobuten-1,2-diyl radical or a radical of the formula C.dbd.Z in which Z is an oxygen or sulphur atom or a radical of the formula NCN, NNO.sub.2, CHNO.sub.2, NCONH.sub.2, C(CN).sub.2, NCOR.sup.5, NCO.sub.2 R.sup.5, NSO.sub.2 R.sup.5 or NR.sup.6 in which R.sup.5 is an alkyl or haloalkyl radical of 1 to 6 carbon atoms, a phenyl or alkylphenyl radical of 6 to 10 carbon atoms or a pyridyl radical and R.sup.6 is a hydrogen atom, an alkyl or haloalkyl radical of 1 to 6 carbon atoms or a phenyl or alkylphenyl radical of 6 to 10 carbon atoms;
• B is an alkyl, alkoxy or alkylthio radical of 1 to 6 carbon atoms or a radical of the formula NR.sup.7 R.sup.8 in which R.sup.7 and R.sup.8, which may be the same or different, are hydrogen atoms, alkyl, phenyl, haloalkyl or alkoxycarbonyl radicals of 1 to 6 carbon atoms, alkenyl or alkynyl radicals of 3 to 6 carbon atoms in which the double or triple bond respectively is separated from the nitrogen atom of NR.sup.7 R.sup.8 by at least one carbon atom, (primary hydroxy)alkyl or (primary amino)alkyl radicals of 2 to 6 carbon atoms, alkylaminoalkyl or dialkylaminoalkyl radicals of up to 8 carbon atoms in which the nitrogen atom is separated from the nitrogen atom of NR.sup.7 R.sup.8 by at least two carbon atoms or cycloalkyl radicals of 3 to 8 carbon atoms, or R.sup.7 and R.sup.8 are joined to form, together with the nitrogen atom to which they are attached, a 5- or 6-membered saturated ring which optionally contains an oxygen atom or an NR.sup.9 radical in which R.sup.9 is a hydrogen atom or an alkyl radical of 1 to 6 carbon atoms;
• and the pharmaceutically-acceptable acid-addition salts thereof.