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US 4,362,726 AGranted
Substituted-1,2,5-thiadiazole-1-oxide compounds, compositions and use
AssigneeMerck & Co., Inc.
InventorsJoseph S. Amato, Sandor Karady, Leonard M. Weinstock
Life of this patent
Estimating the term…
Abstract
Substituted-1,2,5-thiadiazole-1-oxides, their preparation and pharmaceutical use as elastase inhibitors are disclosed.
Claims20
Compounds having the formula:
- ##STR6## wherein:
- (a) Y is either O or NH;
- and
- (b) X is a 6-membered nitrogen containing heterocyclic ring which may also contain an oxygen or N--R" heteroatom, said heterocyclic ring selected from morpholine, piperidine, piperazine and N-lower-alkyl piperazine, wherein R" is hydrogen or lower-alkyl;
- and
- (c) R is alkyl, benzyl, monohalogen-substituted-benzoyl, lower-alkyl-substituted anilino carbonyl, N-lower-alkyl carbamoyl, lower-alkoxy carbonyl, lower-alkylcarbonyllower-alkyl, phenylcarbonyllower-alkyl, monohalogen-substituted phenylcarbonyllower-alkyl and lower-alkoxy-carbonyllower-alkyl.
3 more elements
Compounds having the formula:
- ##STR7## wherein:
- (a) Y is NH;
- and
- (b) X is a 6-membered nitrogen containing heterocyclic ring which may also contain an oxygen or N--R" heteroatom, said heterocyclic ring selected from morpholine, piperidine, piperazine and N-lower-alkyl piperazine, wherein R" is hydrogen or lower-alkyl;
- and
- (c) R is alkyl, benzyl, monohalogen-substituted-benzoyl, lower-alkyl-substituted anilino carbonyl, N-lower-alkyl carbamoyl, lower-alkoxy carbonyl, lower-alkylcarbonyllower-alkyl, phenylcarbonyllower-alkyl, monohalogen-substituted phenylcarbonyllower-alkyl and lower-alkoxy-carbonyllower-alkyl.
3 more elements
Dependencies are inferred from the claim text.