Tissue adhesive
AssigneeImmuno Aktiengesellschaft fur chemisch-medizinische Produkte
InventorsOtto Schwarz, Yendra Linnau, Franz Loblich, Thomas Seelich
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Abstract
A tissue adhesive on the basis of human or animal protein contains factor XIII and at least 33% by weight of fibrinogen, has a ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen, of at least 80, contains fibrinogen and albumin in the total protein at a ratio of 33 to 90:5 to 40, contains plasminogen-activator-inhibitor or plasmin inhibitor in an amount of 250 to 25,000 KIU per g of fibrinogen and has been lyophilized.
Claims9
A lyophilized tissue adhesive of mammalian protein origin which comprises fibrinogen, albumin, factor XIII, cold-insoluble globulin and plasminogen-activator inhibitor or plasmin inhibitor wherein the fibrinogen is present in at least 33% by weight, the ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen is at least 80;
- and fibrinogen and albumin are present in a ratio of 33 to 90:5 to 40.
Dependencies are inferred from the claim text.