Pyridopyrimidinone derivatives

Abstract

Derivatives of pyridopyrimidinone of the following formulae: ##STR1## wherein Y is C.dbd.S, C.dbd.O, SO.sub.2, or CH.sub.2 ; Z is C--H, N, S or O; R.sub.1 is hydrogen, hydroxyl, halogen, lower alkyl or R.sub.3 ; R.sub.2 is hydrogen, aliphatic hydrocarbon, substituted aliphatic hydrocarbon or carbocyclic aryl-aliphatic hydrocarbon, wherein the substituent of the aliphatic hydrocarbon may be hydroxyl, halogen, alkoxy, carboxylic acid ester, or lower alkyl amine; R.sub.3 is ##STR2## wherein A is carbon, nitrogen, oxygen, or sulfur; R.sub.6 is hydrogen, aliphatic hydrocarbon, substituted aliphatic hydrocarbon, aryl, substituted aryl, substituted carbocyclic aryl, carbocyclic aryl-lower aliphatic hydrocarbon, heterocyclic moiety, substituted heterocyclic moiety, heterocyclic aryl or heterocyclic aryl-lower aliphatic hydrocarbon, ##STR3## where A is carbon, nitrogen, oxygen or sulfur, ##STR4## having 0, 1 or 2 double bonds where X is N, O or S; wherein the substituent group may be hydroxyl, halogen, nitro, lower alkyl, alkoxy, carboxylic acid ester, lower alkyl amine, or sulfamoyl; and R.sub.4 and R.sub.5 may by lower alkyl, substituted aromatic, halogen or hydrogen. These compounds are useful for treating conditions associated with excess fluid retention and excess electrolyte retention.

Dependencies are inferred from the claim text.