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US 4,361,699 AGranted
Novel process for the preparation of N.sup.6 -alkyl-arprinocid
AssigneeMerck & Co., Inc.
InventorsGary H. Rasmusson, Richard L. Tolman
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Abstract
This invention is concerned with a novel process for the preparation of N.sup.6 -alkyl-arprinocid (6-alkyl-amino-9-substituted benzyl purines). Such compounds are active anticoccidial agents. The process involves the preparation of a Schiff base from an acetal of dialkylformamide and reduction with a metal hydride.
Claims8
A process for the preparation of a compound having a formula:
- ##STR2## wherein R.sub.1 and R.sub.2 are halogen and R.sub.3 is hydrogen or loweralkyl which comprises treating a compound having the formula:
- ##STR3## wherein R.sub.1 and R.sub.2 are as defined above with a compound having the formula:
- ##STR4## wherein R.sub.3 is defined above and R.sub.4 and R.sub.5 are lower alkyl and R" is lower alkyl, to prepare a compound having the formula:
- ##STR5## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined above which is treated with a reducing agent and a dipolar solvent to produce the desired compound.
1 more element
A process for the preparation of the compound having the formula:
- ##STR6## wherein R.sub.1 and R.sub.2 are halogen and R.sub.3 is hydrogen or lower alkyl which comprises treating a compound having the formula:
- ##STR7## wherein R.sub.4 and R.sub.5 are lower alkyl, with a reducing agent in a dipolar solvent to produce the desired compound.
Dependencies are inferred from the claim text.