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US 4,361,673 AGranted
Polypeptide compositions
AssigneeAmerican Home Products Corporation
InventorWilliam H. McGregor
Life of this patent
Estimating the term…
Abstract
There are disclosed polypeptides having the formula: R.sub.1 --Lys--Lys--X--R.sub.2 wherein R.sub.1 is hydrogen or p-Glu; X is Glu or Asp; and R.sub.2 is Val, NH.sub.2 or Val-NH.sub.2 ; the fully protected peptide-resin intermediates thereof and pharmaceutically acceptable salts thereof. These polypeptides have the capability of inducing the maturation of T-cell populations and thus are useful in a number of therapeutic areas.
Claims9
A polypeptide having the following formula:
- R.sub.1 -lys-Lys-X-R.sub.2
- wherein R.sub.1 is hydrogen or p-Glu;
- X is Glu or Asp;
- and R.sub.2 is Val, NH.sub.2 or Val-NH.sub.2 ;
- the fully protected peptide-resin intermediates thereof, and pharmaceutically acceptable salts thereof.
2 more elements
A compound of the formula:
- ##STR2## wherein R.sub.1 is hydrogen or p-Glu;
- X is Glu or Asp;
- and R.sub.2 is Val, NH.sub.2 or Val-NH.sub.2 ;
- A is an amino protecting group;
- and B is a carboxy protecting group.
2 more elements
Dependencies are inferred from the claim text.