Back to results
US 4,361,650 AGranted
Fermentation process of preparing demethyl maytansinoids
AssigneeTakeda Chemical Industries, Ltd.
InventorsMitsuko Asai, Kazuo Nakahama, Motowo Izawa
Life of this patent
Estimating the term…
Abstract
Novel demethylmaytansinoids representable by the formula: ##STR1## (wherein X is Cl or H; R.sub.1 is H or acyl group) are produced from maytansinoids by means of enzymic transformation. The demethylmaytansinoids are useful as antifungal, antiprotozoal or antitumor agents.
Claims8
A method for producing a demethylmaytansinoid compound of the formula:
- ##STR23## (wherein X is Cl or H;
- R.sub.1 is H or acyl) characterized in that a maytansinoid compound of the formula:
- ##STR24## (wherein X and R.sub.1 are as respectively defined above) is contacted with a culture broth, inclusive of a processed matter of the culture broth, of a microorganism belonging to the genus Bacillus, the genus Streptomyces or the genus Actinomyces which is able to transform the 20-methoxy group of said maytansinoid compound into a hydroxy group.
A method for producing a demethylmaytansinoid compound of the formula:
- ##STR25## (wherein X is Cl or H) characterized in that a maytansinoid compound of the formula:
- ##STR26## (wherein X is as defined above;
- R.sub.1 ' is acyl group) is contacted with a culture broth, inclusive of a processed matter of the culture broth, of a microorganism of the genus Bacillus, the genus Streptomyces or the genus Actinomyces which is able to transform the 20-methoxy group of said maytansinoid compound into a hydroxy group to obtain a compound of the formula:
- ##STR27## (wherein X and R.sub.1 ' are as respectively defined above) and this latter compound is then subjected to deacylation.
1 more element
Dependencies are inferred from the claim text.