Aluminum ibuprofen pharmaceutical suspensions
AssigneeThe Upjohn Manufacturing Company
InventorsSusanne M. Peck, Lois J. Larion, Englebert L. Rowe
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Abstract
Aluminum ibuprofen pharmaceutical liquid suspensions having improved resistance to dissolution rate reduction upon storage containing aluminum ibuprofen, a suspending agent have a particle size below 50 microns, a water-soluble surface active agent, water, and preferably also from 5 to 30 grams of sucrose per 100 ml of suspension are disclosed, or its sweetening equivalent of glucose, fructose, sodium saccharin sodium cyclamate, or mixtures thereof.
Claims15
A pharmaceutical liquid suspension composition consisting essentially of, for each 100 ml of suspension, (a) from about 4 to about 17 gms of an aluminum salt of ibuprofen,
- (b) from about 0.2 to about 1.1 gms of a pharmaceutically acceptable suspending agent having an average particle size below about 50 microns,
- (c) from about 0.3 to about 0.7 gms of a non-toxic pharmaceutically acceptable essentially water soluble surface active agent, and
- (d) sufficient water to bring the liquid volume to 100 ml of total liquid suspension.
Dependencies are inferred from the claim text.