.alpha.,.alpha.-Diaryl-.beta.-(tert-amino)-propanols and diuretic pharmaceutical compositions containing them
AssigneeTemmler AG
InventorsWilhelm A. Behrendt, Bernhard Stieh
Life of this patent
Estimating the term…
Abstract
.alpha.,.alpha.-Diaryl-.beta.-(tert-amino)-propanols having the general formula: ##STR1## wherein R', R" and R.sup.1 to R.sup.10 represent certain specific substituent groups, exhibit a diuretic and saluretic activity. Pharmaceutical composition containing at least one compound of the general Formula II together with a pharmaceutically acceptable diluent or carrier. The pharmaceutical compositions may be in a form suitable for oral or parenteral administration.
Claims34
1-(4'- Methoxy-2'-methyl-5'-isopropylphenyl)-1-phenyl-2-piperidino-propan-1-ol.
1-(4'-Methoxy-2'-methyl-5'-tert-butyphenyl)-1-phenyl-2-pyrrolidino-propa n-1-ol.
1-(2 '-Methoxy-3'-methyl-5'-tert-butylphenyl)-1-phenyl-2-piperidino-propan-1-ol.
1-(4'-Methoxy-3',5'-diisopropylphenyl)-1-(3",4"-dimethoxyphenyl)-2-piper idino-propan-1-ol.
1-(2'-Methoxy-3 '-methyl-5'-tert-hexylphenyl)-1-phenyl-2-pyrrolidino-propan-1-ol.
1-4'-Methoxy-2',3',5',6'-tetramethylphenyl)-1-phenyl-2-piperid ino-propan-1-ol.
1-(4'-Methoxy -3',5'-diisopropylphenyl)-1-(4"-methoxyphenyl)-2-piperidino-propan-1-ol.
1-(4'-Methoxy-3',5'-diisopropylphenyl)-1-(4"ethoxyphenyl)-2-piperidino-p ropan-1-ol.
1-(4'-Me thoxy-3',5'-diisopropylphenyl)-1-(4"-methoxy-3",5"-dimethylphenyl)-2-piperi dino-propan-1-ol.
1-(4'-Ethoxy- 3'5'-diisopropylphenyl)-1-(4"-methoxyphenyl)-2-piperidino-propan-1-ol.
1-(3'-Chloro-6'methoxy-2'-methyl-5'isopropylphenyl)-1-phenyl-2-pyr rolidino-propan-1-ol.
(1-(4'-Ethoxy-3', 5'-diisopropylphenyl)-1-(4"-ethoxyphenyl)-2-piperidino-propan-1-ol.
1-(2'-Methoxy-3'methyl-5'-tert-butylphenyl)-1-(2",4"-dimethoxyp henyl)-2-piperidino-propan-1-ol.
1-(2'-Methoxy-3'-methyl-5'-tert-butyphenyl)-1-(2"-(or 4") hydroxy-4" (or 2")-methoxyphenyl-2-piperidino-propan-1-ol.
1-(2'-Methoxy-3'-methyl-5'-tert-butylphenyl) -1-(3",4"-dimethoxyphenyl)-2-piperidino-propan-1-ol.
1-(2'-methoxy-5'-methylphenyl)-1-(4"-benzyloxy-3 ",5"-diisopropylphenyl)-2-piperidino-propan-1-ol.
1-(3'-chloro-6'-methoxy-5'-methylphenyl)-1-(4 "-methoxy-3",5"-dimethylphenyl)-2-(N-methyl-tertiarybutylamino)-propan-1-ol
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(4'-methoxy-2'-methyl-5'-isopropylphenyl)-1-phenyl-2-piperidino-propan-1 -ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(4'-methoxy-2'-methyl-5'-tert-butylphenyl)-1-phenyl-2-pyrrolidino-propan -1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(2'-methoxy-3'-methyl-5'-tert-butylphenyl)-1-phenyl-2-piperidino-propan- 1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(4'-methoxy-3',5'-diisopropylphenyl)-1-(3",4"-dimethoxyphenyl)-2-piperid ino-propan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(2'-methoxy-3'-methyl-5'-tert-hexylphenyl)-1-phenyl-2-pyrrolidino-propan -1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(4'-methoxy-2',3',5',6'-tetramethylphenyl)-1-phenyl-2-piperidino-propan- 1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(4'-methoxy-3',5'-diisopropylphenyl)-1-(4"-methoxyphenyl-2-piperidino-pr opan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(4'-methoxy-3',5'-diisopropylphenyl)-1-(4"ethoxyphenyl)-2-piperidino-pro pan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(4'-methoxy-3',5'-diisopropylphenyl)-1-(4"-methoxy-3",5"-dimethylphenyl) -2-piperidino-propan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(4'-ethoxy-3'5'-diisopropylphenyl)-1-(4"-methoxyphenyl)-2-piperidino-pro pan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(3'-chloro-6'methoxy-2'-methyl-5'isopropylphenyl)-1-phenyl-2-pyrrolidino -propan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(4'-ethoxy-3',5'-diisopropylphenyl)-1-(4"-ethoxyphenyl)-2-piperidino-pro pan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(2'-methoxy-3'methyl-5'-tert-butylphenyl)-1-(2",4"-dimethoxyphenyl)-2-pi peridino-propan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(2'-methoxy-3'-methyl-5'-tert-butylphenyl)-1-(2"-(or 4") hydroxy-4" (or 2")-methoxyphenyl-2-piperidino-propan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(2'-methoxy-3'-methyl-5'-tert-butylphenyl)-1-(3",4"-dimethoxyphenyl)-2-p iperidino-propan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(2'-methoxy-5'-methylphenyl)-1-(4"-benzyloxy-3",5"-diisopropylphenyl)-2- piperidino-propan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
A diuretic composition wherein the active ingredient is an effective diuretic amount of 1-(3'-chloro-6'-methoxy-5'-methylphenyl)-1-(4"-methoxy-3",5"-dimethylpheny l)-2-(N-methyl-tertiary-butylamino)-propan-1-ol, together with a pharmaceutically acceptable diluent or carrier.
Dependencies are inferred from the claim text.