3-Carbamoyl-6-aminopyridinium and analogues, and their use in treating skin disorders
OwnerEugene J. Van Scott, Ruey J. Yuinventors
Life of this patent
Estimating the term…
Abstract
Systemic as well as topical treatment to alleviate the symptoms of skin disorders characterized by inflammation or disturbed keratinization comprising as the principal active ingredient, one or more 3-carbamoyl-6-aminopyridinium compounds, is disclosed. In the topical treatment the therapeutic composition may include one or more of the above active ingredients present in a total amount of from 0.01 to 5 percent by weight of the total composition. In the systemic treatment oral administration or parenteral injection in a total dosage of from 1 mg/kg to 50 mg/kg has been found to achieve a substantial improvement to complete remissions of the skin lesions, and to ameliorate the symptoms of arthritis that may be associated therewith.
Claims33
A 6-aminonicotinamide pyridinium compound effective on topical or systemic administration to alleviate the symptoms of skin disorders due to inflammation and disturbed keratinization comprising:
- a compound having the formula:
- ##STR4## wherein:
- O.sub.* =O or S
- R=a lower alkyl, carbamoyl lower alkyl, phenyl, phenyl lower alkyl or carboxy lower alkyl group
- or its intermolecular salt with a therapeutically or pharmaceutically acceptable organic or inorganic acid anion, or its intramolecular salt with a carboxylic acid anion.
A 6-aminonicotinic acid pyridinium compound effective on topical or systemic administration to alleviate the symptoms of skin disorders due to inflammation and disturbed keratinization comprising:
- a compound having the formula:
- ##STR5## wherein:
- O.sub.* =O or S
- R=a lower alkyl, carbamoyl lower alkyl, phenyl, phenyl lower alkyl, or carboxy lower alkyl group
- R.sub.1 =H or an organic or inorganic cation or its intermolecular salt with a therapeutically or pharmaceutically acceptable organic or inorganic anion, or its intramolecular salt with a carboxylic acid anion.
A 6-aminonicotinate pyridinium compound effective on topical or systemic administration to alleviate the symptoms of skin disorders due to inflammation and disturbed keratinization comprising:
- a compound having the formula:
- ##STR6## wherein:
- O.sub.* =O or S
- R=a lower alkyl, carbamoyl lower alkyl, phenyl, phenyl lower alkyl or carboxy lower alkyl group
- R.sub.1 =an alkyl radical having from 1-to-9 carbon atoms or an aryl radical having from 6 to 9 carbon atoms
- or its intermolecular salt with a therapeutically or pharmaceutically acceptable organic or inorganic anion or its intramolecular salt with a carboxylic acid anion.
A method for treating the symptoms of skin disorders in humans due to inflammation and disturbed keratinization comprising:
- topically administering to involved skin a symptom alleviating effective amount of a compound having the formula:
- ##STR7## wherein:
- O.sub.* =O or S
- R=a lower alkyl, carbamoyl lower alkyl, phenyl, phenyl lower alkyl, or carboxy lower alkyl group
- or its intermolecular salt with a therapeutically or pharmaceutically acceptable organic or inorganic anion, or its intramolecular salt with a carboxylic acid anion, in a pharmaceutically acceptable vehicle for topical administration.
A method for treating the symptoms of skin disorders in humans due to inflammation and disturbed keratinization comprising:
- topically administering to involved skin a symptom alleviating effective amount of a compound having the formula:
- ##STR8## wherein:
- O.sub.* =O or S
- R=a lower alkyl, carbamoyl lower alkyl, phenyl, phenyl lower alkyl or carboxy lower alkyl group
- R.sub.1 =H or an organic or inorganic cation or its intermolecular salt with a therapeutically or pharmaceutically acceptable organic or inorganic anion, or its intramolecular salt with a carboxylic anion, in a pharmaceutically acceptable vehicle for topical administration.
A method for treating the symptoms of skin disorders in humans due to inflammation and disturbed keratinization comprising:
- topically administering to involved skin a symptom alleviating effective amount of a compound having the formula:
- ##STR9## wherein:
- O.sub.* =O or S
- R=a lower alkyl, carbamoyl lower alkyl, phenyl, phenyl lower alkyl or carboxy lower alkyl group
- R.sub.1 =an alkyl radical having from 1-to-9 carbon atoms or an aryl radical having from 6-to-9 carbon atoms or its intermolecular salt with a therapeutically or pharmaceutically acceptable organic or inorganic anion or its intramolecular salt with a carboxylic acid anion, in a pharmaceutically acceptable vehicle for topical administration.
A method for treating the symptoms of skin disorders in humans due to inflammation and disturbed keratinization comprising:
- administering a therapeutic and symptom alleviating effective amount in total dosage of from 1 to 50 mg/kg body weight of a compound having the formula:
- ##STR10## wherein:
- O.sub.* =O or S
- R=a lower alkyl, carbamoyl lower alkyl, phenyl, phenyl lower alkyl, or carboxy lower alkyl group
- or its intermolecular salt with a therapeutically or pharmaceutically acceptable organic or inorganic anion, or its intramolecular salt with a carboxylic acid anion.
A method for treating the symptoms of skin disorders in humans due to inflammation and disturbed keratinization comprising:
- administering a therapeutic and symptom alleviating effective amount in total dosage of from 1 to 50 mg/kg of body weight of a compound having the formula:
- ##STR11## wherein:
- O.sub.* =O or S
- R=a lower alkyl, carbamoyl lower alkyl, phenyl, phenyl lower alkyl or carboxy lower alkyl group
- R.sub.1 =H or an organic or inorganic cation or its intermolecular salt with a therapeutically or pharmaceutically acceptable organic or inorganic anion, or its intramolecular salt with a carboxylic acid anion.
A method for treating the symptoms of skin disorders in humans due to inflammation and disturbed keratinization comprising:
- administering a therapeutic and symptom alleviating effective amount in total dosage of 1 to 50 mg/kg body weight of a compound having the formula:
- ##STR12## wherein:
- O.sub.* =O or S
- R=a lower alkyl, carbamoyl lower alkyl, phenyl, phenyl lower alkyl or carboxy lower alkyl group
- R.sub.1 =an alkyl radical having from 1-to-9 carbon atoms or an aryl radical having from 6-to-9 carbon atoms
- or its intermolecular salt with a therapeutically or pharmaceutically acceptable organic or inorganic anion or its intramolecular salt with a carboxylic acid anion.
Dependencies are inferred from the claim text.