3-Aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them

A compound of formula I, ##STR58## wherein R.sub.1 is hydrogen or methyl,

• R.sub.2 is cyano and
• R is:
• (a) a group --B--CO--R.sub.h, wherein
• B is a group (i), (ii) or (iii), groups (i), (ii) and (iii) having the following significances:
• (i) ##STR59## wherein R.sub.i is hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or phenyl monosubstituted or independently disubstituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35;
• (ii) ##STR60## wherein R.sub.j is hydrogen or alkyl of 1 to 4 carbon atoms;
• (iii) ##STR61## wherein n is 2, 3 or 4,
• R.sub.k is hydrogen or alkyl of 1 to 4 carbon atoms and
• R.sub.l has the significance indicated above for R.sub.i, and
• R.sub.h is phenylalkyl of 7 to 11 carbon atoms or diphenylalkyl of 13 to 17 carbon atoms, any of the phenyl rings of these two groups optionally being mono- or independently disubstituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35;
• (b) a group ##STR62## wherein R.sub.m is --COR.sub.n or --R.sub.p, wherein
• R.sub.n has the significance indicated above for R.sub.h and
• R.sub.p is phenyl monosubstituted by alkoxy of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35, phenyl independently disubstituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35, phenylalkyl of 7 to 11 carbon atoms or diphenylalkyl of 13 to 17 carbon atoms, any of the phenyl rings of these last two groups optionally being mono- or independently disubstituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35,
• and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, or a pharmaceutically acceptable salt thereof.