1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor

A D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanol acylate of the following formula:

• ##STR8## wherein R is a member selected from the group consisting of methyl or ethyl or a halogenated derivative thereof, dihalogenodeuteriomethyl, 1-halogeno-1-deuterioethyl, 1,2-dihalogeno-1-deuterioethyl, azidomethyl and methylsulfonylmethyl;
• each of X and X' is a member selected from the group consisting of NO.sub.2, SO.sub.2 R.sub.1, SOR.sub.1, SR.sub.1, SONH.sub.2, SO.sub.2 NH.sub.2, SONHR.sub.1, SO.sub.2 NHR.sub.1, COR.sub.1, OR.sub.1, R.sub.1, CN, halogen, hydrogen, phenyl and phenyl substituted by halogen, NO.sub.2, SO.sub.2 CH.sub.3, R.sub.1 or OR.sub.1, wherein
• R.sub.1 is methyl, ethyl, n-propyl or isopropyl;
• and
• Z is an acyl radical of a hydrocarboncarboxylic acid or an acyl radical of a hydrocarbondicarboxylic acid having up to 16 carbon atoms or an acyl radical of an aminohydrocarboncarboxylic acid having up to 12 carbon atoms;
• and the pharmaceutically acceptable salts of said acyl radicals.