Back to results
US 4,361,553 AGranted
Therapeutic uses of dynorphin
AssigneeThe Regents of the University of California
InventorsHorace H. Loh, Nancy M. Lee
Life of this patent
Estimating the term…
Abstract
A therapeutic method of using dynorphin comprises administering dynorphin to a host tolerant to narcotic analgesics. Practice of the therapeutic method provides that lower doses of a narcotic analgesic may be used, such as for patients requiring chronic treatment with narcotics to ease pain, and for treatment of narcotics addicts.
Claims11
A therapeutic method of using dynorphin comprising:
- administering a dynorphin dose, said dynorphin dose including a polypeptide having at least the sequence TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO, the TYR-GLY-GLY-PHE-LEU portion of said sequence defining an N-terminal end for said polypeptide, the administering being to a host tolerant to a narcotic analgesic.
A therapeutic method of producing analgesia in a host tolerant to a narcotic analgesic comprising the steps of:
- determining a first dose of said narcotic analgesic, said first dose being sufficient to produce an analgesic level in the host;
- administering a predetermined dose of said narcotic analgesic to the host, said second host being lower than said first dose of the determining step;
- and,
- supplementing said second dose with a third dose, said third dose including dynorphin-(1-13), the supplementing being sufficient to produce a level of analgesia in the host which is substantially equivalent to the analgesic level of the determining step.
1 more element
Dependencies are inferred from the claim text.