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AssigneeBoehringer Ingelheim GmbH
InventorsHerbert Stricker, Bernhard Freund, Heribert Harwalik, Karl L. Rominger, Siegfried Darda, Volkmar Haselbarth, Dietrich Arndts, Wolf D. Bechtel, Gerhard Bozler, Rolf Brickl, Peter Gruber
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A pharmaceutical dosage unit retard form having a constant, pH-independent release rate of active ingredient, consisting of a core comprising an active ingredient, and a semi-permeable diffusion coating over the core, were the coating consists of a water-insoluble film-former, a water-soluble polymer and eventually an acid-insoluble polymer incorporated therein.
A pharmaceutical dosage unit composition consisting essentially of a gelatin capsule containing (1) a disintegrating core comprising (i) dipyridamole or an acid addition salt thereof and (ii) an acid substance in an amount sufficient to make the dipyridamole water-soluble and having a readily water-soluble coating, and (2) a plurality of non-disintegrating cores comprising (i) dipyridamole or an acid addition salt thereof and (ii) an acid substance in an amount sufficient to make the dipyridamole water-soluble and having a coating consisting of from 20 to 90 percent by weight of a water-insoluble film former and from 10 to 80 percent by weight of a water-soluble polymer, the diameter of each of the disintegrating and non-disintegrating cores being at least about 5 mm.
Dependencies are inferred from the claim text.