Antibiotic nodusmicin derivatives
AssigneeThe Upjohn Company
InventorsBarney J. Magerlein, Howard A. Whaley
Life of this patent
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Abstract
Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.
Claims11
A compound of the formula ##STR3## wherein R is H in no more than two positions at the same time, a blocking group which will be removed prior to the obtention of the end product, said blocking group selected from the group consisting of trisubstituted silyl ethers, tetrahydropyranyl ethers, .beta.,.beta.,.beta.-trichloroethyl ether, and carbonate esters in at least one position, or an hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive;
- or a halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, or loweralkoxy-substituted hydrocarbon acyl radical of from 2 to 18 carbon atoms, inclusive;
- and loweralkoxycarbonyl.
18-O-Benzoate ester of antibiotic nodusmicin.
9-O-Benzoate ester of antibiotic nodusmicin.
18-O-t-Butyldimethylsilyl ether of antibiotic nodusmicin.
18,9-O-Di-t-butyldimethylsilyl ether of antibiotic nodusmicin.
9-O-Benzoyl-18-O-butyldimethylsilyl ester of antibiotic nodusmicin.
11-O-Benzoyl-18-O-butyldimethylsilyl ester of antibiotic nodusmicin.
9,11-O-Dibenzoyl-18-O-butyldimethylsilyl ester of antibiotic nodusmicin.
Dependencies are inferred from the claim text.