Fermentation process for producing anandimycin
AssigneeBristol-Myers Company
InventorsDavid M. Balitz, James A. Bush, Frances A. O'Herron, Donald E. Nettleton, Jr.
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Abstract
A polycyclic antitumor antibiotic designated herein as anandimycin is produced by fermentation of Streptomyces anandii subsp. araffinosus strain C-22,437 (ATCC 31431). Anandimycin possesses antibacterial activity and inhibits the growth of tumors in experimental animals.
Claims1
A process for producing the antitumor antibiotic anandimycin having the formula ##STR4## which comprises cultivating an anandimycin-producing strain of Streptomyces anandii subsp. araffinosus having the identifying characteristics of ATCC 31431, or a mutant thereof, in an aqueous nutrient medium under submerged aerobic conditions until a substantial amount of anandimycin is produced by said organism in said culture medium and recovering the anandimycin from the culture medium substantially free of substances co-produced therewith.
Dependencies are inferred from the claim text.