Substituted chromans
AssigneeE. R. Squibb & Sons, Inc.
InventorJoseph E. Sundeen
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Abstract
The invention relates to chroman derivatives of the general formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, substituted phenyl, phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl or lower alkyl-amino-lower alkyl; R.sub.2 is ##STR2## R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each is independently selected from hydrogen, hydroxy, amino, -o-acyl, -o-lower alkyl; ##STR3## halogen, lower alkyl, or halo substituted lower alkyl; and salts and hydrates thereof. These compounds are useful as anti-inflammatory agents; for inhibition of blood platelet aggregation, as antiallergy and as antihypertensive agents.
Claims15
A compound of formula ##STR94## wherein R.sub.1 is hydrogen, lower alkyl, substituted phenyl wherein the substituent is one or two halogen, lower alkyl or lower alkoxy groups, phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl wherein the substituent is one or two halogen, lower alkyl or lower alkoxy groups, or lower alkyl-amino-lower alkyl;
- R.sub.2 is ##STR95## R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each is independently selected from hydrogen, hydroxy, amino, lower alkanoyloxy, --O--lower alkyl, ##STR96## halogen, lower alkyl, or halo substituted lower alkyl;
- and a physiologically acceptable acid-addition salt or hydrate thereof.
The compound of claim 3, 6-amino-3,4-dihydro-N,2-dimethyl-N-nonyl-2H-1-benzopyran-2-propanamine, hydrochloric (1:2).
A compound having the name 3,4-dihydro-2-methyl-2-[(methylamino)propyl]-2H-1-benzopyran-8-ol, or its hydrochloride salt (1:1).
Dependencies are inferred from the claim text.