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US 4,360,525 AGranted
Dibenzazepine derivatives, pharmaceutical compositions containing them, and methods of use
AssigneeSandoz Ltd.
InventorWerner Muller
Life of this patent
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Abstract
Dibenzazepine derivatives in free base form or in pharmaceutically acceptable acid addition salt form are useful as neuroleptic, antidepressant, sleep-inducing, sleep-promoting and sleep-prolonging agents.
Claims36
A compound of formula I, ##STR29## wherein R.sub.1 is hydrogen, C.sub.1-4 -alkyl, C.sub.2-4 -alkyl substituted by cyano, C.sub.2-5 -hydroxyalkyl, C.sub.2-18 -alkanoyloxy-(C.sub.2-5)-alkyl, C.sub.7-9 -phenylalkyl, C.sub.3-6 -cycloalkyl or C.sub.4-7 -cycloalkylalkyl,
- R.sub.2 and R.sub.3 are independently of each other hydrogen, halogen, trifluoromethyl, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy or C.sub.1-4 -alkylthio, and
- Z is --O--, --S-- or --NR--, wherein R is hydrogen, C.sub.1-4 -alkyl, C.sub.3-5 -alkenyl, C.sub.7-9 -phenylalkyl, C.sub.3-6 -cycloalkyl or C.sub.4-7 -cycloalkylalkyl,
- in free base form or in pharmaceutically acceptable acid addition salt form.
Dependencies are inferred from the claim text.