Pharmaceutical formulations of 4'-(9-acridinylamino)-methanesulfon-m-anisidide
AssigneeBristol-Myers Company
InventorsMurray A. Kaplan, Daniel Bouzard, Claude Perol, Jacques Stemer, Abraham Weber
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Abstract
This invention concerns novel water-soluble compositions of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (m-AMSA). More particularly, water-soluble compositions are provided which comprise a mixture of m-AMSA with lactic acid. The compositions enable m-AMSA to be administered as an aqueous solution without the necessity of using dimethylacetamide as a pharmaceutical vehicle.
Claims9
A solid pharmaceutical composition for reconstitution with water to give a stable aqueous solution of m-AMSA, said composition consisting of m-AMSA having the formula ##STR1## in admixture with lactic acid, the molar ratio of lactic acid to m-AMSA being from about 1.5:1 to 4:1.
A solid pharmaceutical composition in unit dosage form for reconstitution with water to give a stable aqueous solution of m-AMSA, said composition consisting of a mixture of about 20 to 200 milligrams of m-AMSA having the formula ##STR2## in admixture with about 1.5 to 4 molar equivalents of lactic acid.
Dependencies are inferred from the claim text.