7[3,6-Dihydro-1(2H)-p yridyl]-2-oxo-2H-[1,2,4]oxadiazolo[2,3-c]pyrimidine-5-carbamate compounds
AssigneeHoffmann-La Roche Inc.
InventorsUrs Hengartner, Jean-Claude Muller, Henri Ramuz
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Abstract
Oxadiazolo[2,3-c]pyrimidine derivatives of the formula ##STR1## wherein R is alkyl, alkenyl, alkynyl or alkoxyalkyl, as well as their salts, are described. The compounds of formula I have valuable, long-lasting vasodilating and/or blood pressure-lowering properties and are useful for the treatment of vascular-conditioned hypertensions or as vasodilators in peripheral blood supply disorders. The compounds are prepared, inter alia, by carbamoylating the corresponding derivative containing a free amino group and optional salt formation.
Claims12
A compound of the formula ##STR11## wherein R is alkyl of 1-8 carbon atoms, alkenyl, of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, or (C.sub.1-8)alkoxy-( C.sub.1-8)alkyl, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound of the formula ##STR12## wherein R is alkyl of 1-8 carbon atoms, alkenyl, of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, or (C.sub.1-8)alkoxy-( C.sub.1-8)alkyl, or a pharmaceutically acceptable salt thereof and an inert carrier material.
Dependencies are inferred from the claim text.