Analgesic method using a morpholine compound
AssigneeJohn Wyeth & Brother Limited
InventorsAlan C. White, Edwin T. Edington
Life of this patent
Estimating the term…
Abstract
Morpholine derivatives of the formula ##STR1## and their pharmaceutically acceptable acid addition salts[wherein R.sup.1 represents lower alkyl. R.sup.2 represents hydrogen, lower alkyl, benzyl, lower alkoxymethyl or an acyl group; R.sup.3 represents hydrogen, lower alkyl or phenyl; R.sup.4, R.sup.5 and R.sup.6 are independently hydrogen or lower alkyl and R.sup.7 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl(lower)alkyl, tetrahydrofurylmethyl or cycloalkylmethyl] possess analgesic and/or opiate antagonistic activity.
Claims1
A method of treating a mammal in need of an analgesic or opiate antagonist which comprises administering to said mammal an analgesically or opiate antagonistically effective amount of a compound selected from the group consisting of a morpholine derivative of the formula:
- ##STR21## and a pharmaceutically acceptable acid addition salt thereof, wherein R.sup.1 represents lower alkyl;
- R.sup.2 represents hydrogen, lower alkyl, benzyl, loweralkoxymethyl or an acyl group;
- R.sup.3 represents hydrogen, lower alkyl or phenyl;
- R.sup.4, R.sup.5 and R.sup.6 are independently hydrogen or lower alkyl and R.sup.7 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl(lower)alkyl, tetrahydrofurylmethyl or cycloalkylmethyl, with the proviso that R.sup.2 may only be lower alkyl when R.sup.7 is other than hydrogen or lower alkyl.
Dependencies are inferred from the claim text.