N'-[2,6-Dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-d imethylformamidines
AssigneeAmerican Cyanamid Company
InventorsWalter E. Meyer, Andrew S. Tomcufcik, Joseph W. Marsico, Jr.
Life of this patent
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Abstract
This disclosure describes novel N'-[2,6-dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-dimethylforma midines which possess activity as hypotensive agents and as diuretics.
Claims12
A compound selected from the group consisting of those of the formula:
- ##STR4## wherein R.sub.1, R.sub.2, R.sub.4 and R.sub.5 are each individually selected from the group consisting of hydrogen, fluoro, chloro, bromo, hydroxy, methoxy, methyl and trifluoromethyl;
- R.sub.3 is selected from the group consisting of hydrogen, fluoro, chloro, bromo, cyano, hydroxy, methoxy, methyl, trifluoromethyl, phenyl, acetamido, dimethylamino and diethylamino;
- and R.sub.2 and R.sub.3 taken together is methylenedioxy with the proviso that at least two of R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen;
- and the pharmacologically acceptable acid-addition salts thereof.
A compound selected from the group consisting of 4'-[N-[3,6-dichloro-4-(dimethylaminomethyleneamino)phenyl]formimidoyl]-3,4 ,5-trimethoxybenzanilide and the pharmacologically acceptable acid-addition salts thereof.
A compound selected from the group consisting of N'-[2,6-dichloro-4-[(p-dimethylaminocinnamylideneamino)phenyl]-N,N-dimethy lformamidine and the pharmacologically acceptable acid-addition salts thereof.
Dependencies are inferred from the claim text.