Synthesis of intermediate for the manufacture of 5,6-dihydro-2-methyl-N-phenyl-1,4-oxathin-3-carboxamide
AssigneeUniroyal, Inc.
InventorsGeorge Liebermann, Frederick M. M. Hager
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Abstract
2-[(2-hydroxyethyl)thio]-3-oxo-N-phenylbutanamide, which is an intermediate useful in the manufacture of the fungicide, 5,6-dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide, is made by reaction of di-(2-hydroxyethyl) disulfide with acetoacetanilide in its ionized form.
Claims10
A method for making 5,6-dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide by cyclization of the intermediate 2-[(2-hydroxyethyl)thio]-3-oxo-N-phenyl-butanamide, in which this intermediate is obtained by the reaction of di-(2-hydroxyethyl) disulfide with acetoacetanilide.
A method for making 2-[(2-hydroxyethyl)thio]-3-oxo-N-phenylbutanamide comprising reacting di-(2-hydroxyethyl) disulfide with acetoacetanilide in an ionized form.
Dependencies are inferred from the claim text.