Thiazine-1,1-dioxide and isothiazole-1,1-dioxide derivatives

A compound of the formula ##STR78## wherein P is a protecting group, R.sup.1 and R.sup.2 each are selected from hydrogen, alkyl, alkoxy, chloro and fluoro;

• R.sup.3 is hydrogen, alkyl, alkoxy, or --OP;
• R.sup.2 and R.sup.3 taken together represent the carbon atoms necessary to complete a fused benzene ring;
• R.sup.4 and R.sup.6 each are selected from hydrogen, alkyl, alkoxy, chloro and fluoro;
• R.sup.5 is hydrogen, alkyl, alkoxy, --OP.sup.I wherein P.sup.I is a protecting group, --N,N-(dialkyl)amino, --N,N-(w-R.sup.8 alkyl).sub.2 amino wherein R.sup.8 is halo or --OP.sup.II wherein P.sup.II is a protecting group, --NHCOCH.sub.3, piperidino, pyrrolidino, N-methylpiperazino, morpholino, thiomorpholino or tetrahydro-2H,4H-1,3,6-dioxazocino;
• R.sup.7 is hydrogen, alkyl, alkoxy or --OP.sup.III wherein P.sup.III is a protecting group the same as P.sup.I or P.sup.II ;
• R.sup.6 and R.sup.7 taken together represent the carbon atoms necessary to complete a fused benzene ring;
• R.sup.4, R.sup.5 and R.sup.6 taken together represent the atoms necessary to complete a fused [ij]quinolizidine ring;
• X represents the atoms necessary to complete 2,3-dihydrobenz[d]isothiazole-1,1-dioxide or 2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxide and R.sup.11 is ##STR79## wherein R.sup.9 is selected from methyl, methyl substituted with at least one halo group selected from chloro, bromo and fluoro, alkoxy having 1 to 4 carbon atoms, phenyl, phenyl substituted in the para position with alkyl having 1 to 4 carbon atoms or --N,N-(dialkyl)amino, phenyl substituted with at least one electron-withdrawing group, phenoxy, phenoxy substituted with at least one electron-withdrawing group, --O(CH.sub.2).sub.2 Y wherein Y is an electron-withdrawing group and phenyl substituted in the ortho position with --CH.sub.2 R.sup.10 wherein R.sup.10 is chloro or bromo.