Enterochelin complexes
AssigneeNational Research Development Corporation
InventorHenry J. Rogers
Life of this patent
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Abstract
Complexes of enterochelin, and certain analogues thereof, with one of the metals indium and scandium are useful for the treatment of bacterial infections.
Claims10
An indium or scandium complex of a compound containing at least one serine moiety in its D- or L- configuration and selected from the group consisting of N,N',N"-tris (2,3-dihydroxybenzoyl)-O-seryl-O-serylserine, N,N'-bis (2,3-dihydroxybenzoyl)-O-serylserine, and derivatives of said compound involving the carboxy and hydroxyl groups of said compound, the derivatives of said carboxy group being pharmaceutically acceptable esters and salts thereof and the derivatives of said hydroxyl group being the resultant double bond from the dehydration of said compound involving said hydroxyl group.
An antibacterial pharmaceutical composition, comprising:
- an antibacterially effective amount of a complex of a compound containing at least one serine moiety in its D- or L- configuration and selected from the group consisting of N,N',N"-tris (2,3-dihydroxybenzoyl)-O-seryl-O-serylserine, N,N'-bis(2,3-dihydroxybenzoyl)-O-serylserine and derivatives of said compound involving the carboxy and hydroxyl groups of said compound, the derivatives of said carboxy group being pharmaceutically acceptable esters and salts thereof and the derivative of said hydroxyl group being the resultant double bond from the dehydration of said compound involving said hydroxyl group, with indium or scandium.
A method of treating bacterial infections in a human or animal subject, comprising:
- administering to said subject an antibacterially effective amount of a complex of a compound containing at least one serine moiety in its D- or L- configuration and selected from the group consisting of N,N',N"-tris(2,3-dihydroxybenzoyl)-O-seryl-O-serylserine, N,N'-bis (2,3-dihydroxybenzoyl)-O-serylserine and derivatives of said compound involving the carboxy and hydroxyl groups of said compound, the derivatives of said carboxy group being pharmaceutically acceptable esters and salts thereof and the derivative of said hydroxyl group being the resultant double bond from the dehydration of said compound involving said hydroxyl group, with indium or scandium.
Dependencies are inferred from the claim text.