Adjacently substituted cycloalkane-amide analgesics

A compound of the formula

• wherein:
• R is hydrogen or C.sub.1 to C.sub.3 -alkyl;
• R.sub.1 and R.sub.2, taken separately, are each hydrogen or C.sub.1 to C.sub.3 -alkyl;
• R.sub.1 and R.sub.2, taken together with the nitrogen to which they are bonded, are azetidinyl, pyrrolidinyl or piperidinyl;
• R.sub.3, taken separately, is hydroxy, C.sub.1 to C.sub.2 -alkyloxy, or C.sub.1 to C.sub.3 -alkanoyloxy;
• R.sub.4, taken separately, is hydrogen when R.sub.3 is hydroxy, C.sub.1 to C.sub.2 -alkyloxy,or C.sub.1 to C.sub.3 -alkanoyloxy;
• R.sub.3 and R.sub.4, taken together, complete a moiety selected from the group, .dbd.G (oxo or thioxo), --G--CH.sub.2 CH.sub.2 --G--, --G--CH.sub.2 CH.sub.2 CH.sub.2 --G--, --G--CH.sub.2 CH(CH.sub.3)CH.sub.2 --G--, --G--CH.sub.2 C(CH.sub.3).sub.2 CH.sub.2 --G--, wherein both G moieties in the same group are oxygen or bivalent sulfur, .dbd.N.about.OH, and .dbd.N.about.OC(.dbd.O)CH.sub.3, wherein each G is oxygen or bivalent sulfur;
• X and Y are independently selected from the group consisting of hydrogen, a halogen having an atomic number from 9 to 35, trifluoromethyl, nitro, methoxy, hydroxy, azido, C.sub.1 to C.sub.3 -alkyl, phenyl, methanesulfonyl, cyano, amino, C.sub.1 to C.sub.3 -alkoxycarbonyl, C.sub.1 to C.sub.3 -alkanoyloxy, C.sub.1 to C.sub.3 -carboxacylamino(--NHC(.dbd.O)R.sub.6, wherein R.sub.6 is hydrogen or C.sub.1 to C.sub.2 -alkyl);
• p and n are whole number integers selected from the group zero, 2, 3, or 4 such that one of p and n is zero and the other of p and n is 2, 3, or 4;
• q is zero or 1;
• E is oxygen or bivalent sulfur;
• provided that when R is C.sub.1 to C.sub.3 -alkyl, R.sub.1 and R.sub.2 taken together with the nitrogen to which they are bonded complete a pyrrolidinyl ring, p is 3 and n is 0, q is 1, X and Y are chlorine in the 3 and 4 positions, R.sub.3 is not hydroxy, C.sub.1 to C.sub.2 -alkoxy or C.sub.1 to C.sub.3 -alkanoyloxy;