Thioketal substituted N-alkyl imidazoles
AssigneeSyntex (U.S.A.) Inc.
InventorKeith A. M. Walker
Life of this patent
Estimating the term…
Abstract
Compounds of the formula: ##STR1## wherein R.sub.1 is phenyl optionally substituted with one or more substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halo, or trifluoromethyl; Z is ethylene or propylene, optionally substituted with a single substituent which is lower alkyl; A is the integer 0, 1, 2, or 3; B is the integer 1, 2, or 3; and wherein the sum of A and B is 1, 2, 3 or 4; and the pharmaceutically acceptable acid addition salts thereof, said compounds being useful as spermicidal, antimicrobial and anticonvulsant agents.
Claims44
A compound having the general formula ##STR7## wherein R.sub.1 is phenyl optionally substituted with one or more substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halo, or trifluoromethyl;
- Z is ethylene or propylene, optionally substituted with a single substituent which is lower alkyl;
- A is the integer 0, 1, 2, or 3;
- B is the integer 1, 2, or 3;
- and
- wherein the sum of A and B is 1, 2, 3 or 4;
- and
- the pharmaceutically acceptable acid addition salts thereof.
A composition useful for combating and controlling the growth of fungi, bacteria or protozoa which comprises an excipient and an effective amount of at least one compound of the formula ##STR8## wherein R.sub.1 is phenyl optionally substituted with one or more substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halo, or trifluoromethyl;
- Z is ethylene or propylene, optionally substituted with a single substituent which is lower alkyl;
- A is the integer 0, 1, 2, or 3;
- B is the integer 1, 2, or 3;
- and
- wherein the sum of A and B is 1, 2, 3 or 4;
- and
- the pharmaceutically acceptable acid addition salts thereof.
A method of combating and controlling the growth of fungi, bacteria and protozoa which comprises administering to a subject host an effective amount of at least one compound of the formula ##STR9## wherein R.sub.1 is phenyl optionally substituted with one or more substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halo, or trifluoromethyl;
- Z is ethylene or propylene, optionally substituted with a single substituent which is lower alkyl;
- A is the integer 0, 1, 2, or 3;
- B is the integer 1, 2, or 3;
- and
- wherein the sum of A and B is 1, 2, 3 or 4;
- and
- the pharmaceutically acceptable acid addition salts thereof.
A spermicidal composition useful for effecting contraception in a male or female mammal which comprises a suitable excipient and an effective amount of a compound of the formula ##STR10## wherein R.sub.1 is phenyl optionally substituted with one or more substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halo, or trifluoromethyl;
- Z is ethylene or propylene, optionally substituted with a single substituent which is lower alkyl;
- A is the integer 0, 1, 2, or 3;
- B is the integer 1, 2, or 3;
- and
- wherein the sum of A and B is 1, 2, 3 or 4;
- and
- the pharmaceutically acceptable acid addition salts thereof.
A method for effecting contraception in a male or female mammal by rendering spermatozoa ineffective, which method comprises administering to a subject an effective amount of at least one compound of the formula ##STR11## wherein R.sub.1 is phenyl optionally substituted with one or more substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halo, or trifluoromethyl;
- Z is ethylene or propylene, optionally substituted with a single substituent which is lower alkyl;
- A is the integer 0, 1, 2, or 3;
- B is the integer 1, 2, or 3;
- and
- wherein the sum of A and B is 1, 2, 3 or 4;
- and
- the pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.