Prostanoic acid derivatives and their preparation

A compound of the formula ##STR69## wherein R.sub.1 is ##STR70## or --NHR.sub.10 wherein R.sub.10 is C.sub.1-10 alkyl, phenyl, 1-naphthyl, or 2-naphthyl, or R.sub.10 is phenyl-, 1-naphthyl- or 2-naphthyl-substituted by 1-3 halolgen atoms, one phenyl group, one to three alkyl groups each of 1-4 carbon atoms, or a chlormethyl, fluoromethyl, trifluoromethyl or alkoxy group, or R.sub.10 is thienyl, furyl, pyridyl, or the acyl radical of an organic carboxylic or sulfonic acid of 1-15 carbon atoms;

• and wherein R.sub.7 and R.sub.8 each are hydrogen atoms or alkyl of 1-4 carbon atoms and R.sub.9 is the acyl radical of an organic carboxylic or sulfonic acid of 1-15 carbon atoms or of an inorganic acid or is ##STR71## R.sub.10 having the definitions given above;
• A is --CH.sub.2 --CH.sub.2 -- or cis- or trans--CH.dbd.CH--;
• B is ##STR72## wherein the methylene group can be in the .alpha.- or .beta.-position;
• W is free or functionally modified hydroxymethylene, a free of functionally modified carbonyl, or ##STR73## wherein R.sub.11 is alkyl of 1-5 carbon atoms and the OH-group can be in the .alpha.- or .beta.-position and can be functionally modified;
• Z is carbonyl or hydroxymethylene, either of which can be free or functionally modified;
• X Y is either ##STR74## when Z is a free or functionally modified hydroxymethylene group, or is either ##STR75## when Z is a free or functionally modified carbonyl group, wherein R.sub.12 is a hydrogen atom, methyl, a cyanide group (--CN), or a free or functionally modified hydroxy;
• R.sub.2 is a hydrogen atom or C.sub.1-5 -alkyl;
• R.sub.3 is a hydrogen atom or C.sub.1-5 -alkyl;
• R.sub.4 and R.sub.5 are each methyl or one of R.sub.4 and R.sub.5 is a chlorine atom and the other is methyl;
• and, when R.sub.6 is hydroxy, the physiologically acceptable salts thereof with bases;
• wherein "functionally modified" OH refers to OH etherified by tetrahydropyranyl, tetrahydrofuranyl, .alpha.-ethoxyethyl, trimethylsilyl, dimethyltert-butylsilyl or tri-p-benzylsilyl or esterified by the acyl group of a C.sub.1-15 organic carboxylic or sulfonic acid;
• and "functionally modified" carbonyl refers to carbonyl converted to a cyclic ketal with ethylene glycol, 1,3-propanediol, 2,2-dimethyl-1,3-propanediol, 1,2-cyclopentanediol, or glycerol.