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US 4,359,464 AGranted
3-Furylmethyl-6-halo-7,8-dihydroxy-1-p henyl-2,3,4,5-tetrahydro-1H-3-benzazepines and antihypertensive use thereof
AssigneeSmithKline Beckman Corporation
InventorJoseph Weinstock
Life of this patent
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Abstract
3-Furylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaze pines have potent dopaminergic activity. As such they have utility as antihypertensive and especially anti-Parkinsonism agents.
Claims7
A compound of the formula:
- ##STR5## in which:
- R is furylmethyl;
- R.sub.1 is halo or trifluoromethyl;
- R.sub.2 and R.sub.3 are hydrogen or lower alkanoyl of from 2-7 carbons;
- and
- R.sub.4 is hydrogen or from 1-3 substituents from the group comprising trifluoromethyl, halo, methyl, methoxy or, when another of this group is present, hydroxy or acetoxy;
- together with its nontoxic, pharmaceutically acceptable salts.
4 more elements
Dependencies are inferred from the claim text.