Antibiotic 67-121, a new polyene antifungal antibiotic produced by Actinoplanes caeruleus
AssigneeSchering Corporation
InventorsMarvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
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Abstract
A microorganism of the genus Acetinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
Claims6
A method of eliciting an antifungal response which comprises administering to an animal having a susceptible fungal infection an antifungal effective dose of the Antibiotic 67-121 Complex, a component thereof, a C.sub.1 -C.sub.4 alkyl ester thereof having the formula ##STR4## wherein R is hydrogen or 1-O-B-D-mannosyl, R.sup.1 is hydrogen or C.sub.1 -C.sub.4 lower alkyl, and the non-toxic pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.