Process for the preparation of substituted guanidines
AssigneeGeneral Electric Company
InventorVictor Mark
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Abstract
Guanidines are one of the strongest organic bases and find applications where this property is needed, such as in phase transfer catalysis in the form of their substituted derivatives. Their use, however, has been hampered by their expensive nature due to the only mediocre yields in their preparation. The present invention provides a process for the preparation of substituted guanidines in high yields.
Claims6
In a process for preparing a guanidine which comprises reacting a substituted (aminomethylene) ammonium halide and a primary amine, the improvement consisting of carrying out the reaction in the presence of at least equimolar amounts of a coreactant strong base selected from the group consisting of
- A. tertiary amines;
- B alkali or alkaline earth metal hydroxides;
- C the guanidine itself that is the product of the reaction;
- D the primary amine reactant itself wherein the primary amine, R'NH.sub.2, is used in at least one molar excess above the stoichiometric amount;
- E quaternary ammonium hydroxides.
The process of claim 8 wherein the primary amine is represented by the following formula:
- R'--NH.sub.2
- wherein R' is alkyl, aryl, aralkyl, alkaryl, cycloalkyl, alkenyl or cycloalkenyl.
Dependencies are inferred from the claim text.