Ebelactones and production thereof
AssigneeZaidan Hojin Biseibutsu Kagaku Kenkyu Kao
InventorsHamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Shinichi Kondo, Masaaki Ishizuka
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Abstract
New physiologically active substances, ebelactone A and ebelactone B which are generally termed ebelactone are produced from a new microorganism, Streptomyces MG7-G1 strain identified FERM-P 5363 or ATCC No. 31860 and ATCC No. 31880. Ebelactone is useful as a host defense stimulator having an activity to enhance cell-mediated immunity, and also as an anti-inflammatory agent.
Claims9
The new compound, ebelactone which is selected from ebelactone A and ebelactone B according to the general formula ##STR3## wherein R is methyl group --CH.sub.3 for ebelactone A and ethyl group --CH.sub.2 CH.sub.3 for ebelactone B.
Ebelactone A of the formula ##STR4##
Ebelactone B of the formula ##STR5##
The process for the production of ebelactone, which comprises cultivating an ebelactone-producing strain of the genus Streptomyces under aerobic conditions in a culture medium containing assimilable carbon and nitrogen sources for a sufficient time to produce and accumulate ebelactone in the culture medium.
The process for the production of ebelactone A which comprises cultivating an ebelactone A-producing strain of Streptomyces under aerobic condtions in a culture medium containing assimilable carbon and nitrogen sources for a sufficient time to produce and accumulate ebelactone A in the culture medium.
The process for the production of ebelactone B which comprises cultivating an ebelactone B-producing strain of Streptomyces under aerobic conditions in a culture medium containing assimilable carbon and nitrogen sources for a sufficient time to produce and accumulate ebelactone B in the culture medium.
Dependencies are inferred from the claim text.