Glaucine phosphate chunky prismatic crystals
AssigneeThe Dow Chemical Company & Merrell Dow Pharmaceuticals Incorporated
InventorChristian T. Goralski
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Abstract
A crystalline form of d,l-glaucine phosphate is prepared by digesting d,l-glaucine phosphate with an alkanol. Glaucine phosphate has potent analgesic and antitussive properties, excellent flavor characteristics and stability properties and the new crystalline form has improved handling properties.
Claims11
Crystalline d,l-glaucine phosphate of chunky prismatic habit, having the morphology of at least three generally parallelepipedal prisms of different sizes fused together with the interfacial junctions being generally in parallel planes.
D,L-Glaucine phosphate, being in the form of chunky prismatic crystalline particles having a length of from about 1 to about 5 times the height thereof, said particles having a morphology resembling polycrystalline particles with generally parallel orientation of the individual crystallites.
D,L-Glaucine phosphate having the crystal morphology illustrated in FIGS. 3 and 4.
A process comprising:
- (a) forming a slurry of d,l-glaucine phosphate in a lower alkanol;
- (b) digesting the slurry at a digestion temperature of from about 50.degree. C. to the boiling temperature;
- (c) thereafter reducing the temperature of the slurry below the digestion temperature range;
- and
- (d) separating crystalline d,l-glaucine phosphate having the crystal morphology illustrated in FIGS. 3 and 4 from the slurry.
D,L-Glaucine phosphate having the crystal morphology illustrated in FIGS. 3 and 4 and prepared by a process consisting essentially of digesting a slurry of d,l-glaucine phosphate in a lower alkanol at a temperature from about 50.degree. C. to the boiling temperature, thereafter reducing the temperature below the digestion temperature range, and separating the resulting D,L-glaucine phosphate product having said crystal morphology.
Dependencies are inferred from the claim text.