Tertiary imidazolyl alcohols and method for the treatment of generalized and local infections caused by fungi and yeasts
AssigneeNordmark-Werke GmbH
InventorsPeter Scharwachter, Klaus Gutsche, Wilhelm Kohlmann, York Hartleben, Wolfgang Heberle
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Abstract
The present invention is directed to new tertiary imidazolyl alcohols having the general formula (I) ##STR1## and to their pharmacologically acceptable acid addition salts with usual acids. The invention is further directed to a method for the treatment of generalized and local infections caused by fungi or yeasts by administering to a mammal suffering from such a disease a compound of the general formula (I) orally or externally in a suitable pharmaceutical preparation.
Claims17
A basic imidazolyl alcohol corresponding to the general formula ##STR12## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each represent a member selected from the group consisting of hydrogen, the halogen atoms, the lower alkyl groups with 1 to 4 carbon atoms and the lower alkoxy groups with 1 to 4 carbon atoms, R.sup.5 represents a member selected from the group consisting of hydrogen and the lower alkyl groups with 1 to 3 carbon atoms and
- n is an integer selected from the group consisting of 0 and 1, and the pharmacologically compatible acid addition salts thereof.
1-Phenyl-2-(4-chlorophenyl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1-Phenyl-2-(2,4-dichlorophenyl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1-(2-Chlorophenyl)-2-(2,4-dichlorophenyl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1-(2-Chlorophenyl)-2-(4-chloro-2-methylphenyl)-3-(imida zol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1-(4-Chlorophenyl)-2-phenyl-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1,2-Bis-(4-chlorophenyl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1-(4-Chlorophenyl)-2-(2,4-dichlorophenyl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1-(2,4-Dichlorophenyl)-2-(4-chlorophenyl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1,2-Bis-(2,4-dichlorophenyl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1-(2,4-Dichlorophenyl)-2-(2-bromo-4-chlorophen yl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1-(2,4-Dichl orophenyl)-2-(3,4-dichlorophenyl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
1-(4-Methylphenyl)-2-(2,4-dichlorophenyl)-3-(imidazol-1-yl)-propan-2-ol and its pharmacologically compatible acid addition salts.
Dependencies are inferred from the claim text.