Antipsychotic piperidinomethyl-indole derivatives
AssigneeJohn Wyeth & Brother Limited
InventorTerence J. Ward
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Abstract
The invention relates to compounds of formula II ##STR1## and their pharmaceutically acceptable salts wherein R.sup.5 represents hydrogen, acyl, lower alkyl or cycloalkyl; R.sup.6 represents hydrogen, halogen, trifluormethyl, or lower alkyl; R.sup.7 represents hydrogen, lower alkyl, hydroxy, lower alkoxy, arylloweralkoxy; R.sup.8 represents hydrogen or lower alkyl; and R.sup.9 represents hydrogen or lower alkyl. The compounds have dopamine blockade activity and may be used in the treatment of psychoses including schizophrenia.
Claims7
A compound of the formula ##STR9## or a pharmaceutically acceptable salt thereof wherein R.sup.6 represents hydrogen, halogen, trifluoromethyl or methyl and R.sup.7 represents hydrogen, methyl, hydroxy or methoxy.
1-(Indol-3-ylmethyl)-4-hydroxy-4-(p-chlorophenyl) piperidine or a pharmaceutically acceptable salt thereof.
1-(Indol-3-ylmethyl)-4-hydroxy-4-phenylpiperidine or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.