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US 4,358,455 AGranted
Aralkylamindethanol heterocyclic compounds
AssigneeMerck & Co., Inc.
InventorsJoseph G. Atkinson, John J. Baldwin, David E. McClure
Life of this patent
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Abstract
Heterocyclic aminoethanols of the formula Het--CHOH--CH.sub.2 --NH--aralkyl where het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
Claims26
Compounds of the formula:
- ##STR48## tautomers, pharmaceutically acceptable salts and individual enantiomers thereof wherein R.sub.1 is H or OH, ##STR49## wherein R.sub.4 and R.sub.5 are independently selected from H and C.sub.1 -C.sub.3 alkyl,
- Y is CH.sub.2, (CH.sub.2).sub.2, (CH.sub.2).sub.3, (CH.sub.2).sub.4 or --CH.sub.2 --O--
- R.sub.6 is H, OH, OCH.sub.3, halogen, methylenedioxy or C.sub.1 -C.sub.3 alkyl and
- n is 1 or 2.
1 more element
Compounds of the formula
- Het-CHOH-CH.sub.2 -NH.sub.2
- wherein Het has the formula ##STR55## tautomers and individual isomers thereof, where R.sub.1 is H or OH.
Dependencies are inferred from the claim text.